Curriculum Mapping System
Learning Activity - Copy of 09 Defence Against Extracellular Pathogens
TypeLecture
ModuleLINCTEST - Lincoln Medicine 1 (Copy of 09 Blood and Immunity)
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Outline the role of antimicrobial defensins.

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Explain how particular isotypes of antibodies interact with defence components by virtue of the properties of their Fc regions.

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Outline the properties of complement and the pathways off complement activation.

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Describe the structure of the membrane attack complex of complement.

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Describe the innate and adaptive mechanisms of opsonisation of microbes for phagocytosis.

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Outline the mechanisms of phagocytosis and intracellular killing.

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Outline the extracellular killing of large parasitic organisms by eosinophils.

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Explain how mast cells can be triggered to release inflammatory mediators.

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Describe the stages of the inflammatory process, and give examples of the main inflammatory mediators.

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Outline the stages of leucocyteendothelial interaction and leucocyte extravasation, and the main adhesion molecules involved in these processes.

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Explain the process of chemotaxis.

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List the main cytokine mediators of the systemic acute phase response, and the processes involved.

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Describe common features of the presentation, investigation and management of a bacterial infection.

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