This module will consist of eleven 2-hour lectures, four 3-hour workshops and three 1-hour tutorials/seminars. It begins with a review of the cytoskeleton and introduction to advanced optical microscopy and tools for studying protein interactions in the cell. Lower level characterization by electron and force microscopy is discussed and the principles of CRISP-cas are discussed. A review of molecular structure is then followed by a discussion of methods for high resolution structural studies of proteins. The module concludes with a brief description of bacterial envelopes and the structure and assembly of inner and outer membranes and the peptidoglycan. 

This module is aimed at introducing the students to the methodological arsenal for studying complex macromolecular systems in vitro and in cells using specific biological examples. It provides an overview of the structures and function of biological macromolecules and macromolecular assemblies with an emphasis on proteins. The module introduces modern structural methods and advanced microscopy techniques in the context of their biological applications.