Only Available for F100, F101, FC1R, FC17, C720, C721, GFC0, FGC0 Available to JYA/Erasmus students.

Palladium catalysis in organis synthesis - Tsuji-Trost pi-allyl chemistry, Heck and Stille reaction, Suzuki, Buchwald-Hartwig and Sonagashira coupling, etc, with synthesis examples


Selectivity issues in organic synthesis Overview of reactivity principles. Synthesis of organometallics (mainly organolithiums) via metal-halogen exchange, metallation etc., including special methods of unsaturated types (Shapiro reaction, ortho-metallation) and heterosubstituted systems. Connective C=C bond formation, including Julia and Peterson olefinations (synthesis examples) and use of sulfur ylides for epoxidation and cyclopropanation. Cuprate chemistry, centred on conjugate addition-electrophilic quench sequences (regiospecfic enolates), but also including carbocupration and substitution. Protecting groups revisited, synthesis of amino acids and peptides. Stereochemistry revised, and an introduction to asymmetric synthesis, including chiral pool, chiral reagents, chial auxiliaries for enolate alkylation and amine synthesis, and catalytic asymmetric oxidation and reduction.

To introduce students to a range of reagents and synthetic methodology, and to describe how it is applied to the synthesis of organic target molecules. How the use of protecting groups can be used to enable complex molecule synthesis. To show how modern palladium-mediated cross-coupling reactions can be used to synthesise useful organic molecules.