This module will present information on the most recent developments in understanding cancer biology. It will include consideration of the biological mechanisms underlying specific cancer types, discussion of how recent genomic studies have led to the identification of genes that play important roles in cancer formation, and outline how molecular genetic techniques are facilitating rapid advances in this field. We will use several medically important forms of cancer, including melanoma, children's cancers and breast and colon cancer to illustrate key concepts in cancer formation and treatment. In addition, we will consider how these advances in the understanding of cancer are influencing the development of new treatments. The recently published "The Biology of Cancer?"by Robert A. Weinberg is an excellent textbook for this course.

This module requires participants to have a good knowledge of gene regulation and its analysis in vertebrates from modules such as LIFE2072 The Genome and Human Disease.

Cancer is one of the major diseases in Western societies, accounting for one third to one quarter of all deaths. Particular attention will focus on the main mechanisms by which cells progress to a tumour state, such as avoiding apoptosis or escaping cell cycle control, and these themes are returned to throughout the course. Recent advances in human molecular genetics have led to the identification of many genes that are responsible for, or contribute towards, the development or progression of cancer. Examples will be provided of genes that are involved in both inherited and sporadic forms of cancer and the latest ideas of the molecular mechanisms underlying cancer will be discussed. Where appropriate, molecular understanding that is leading to new treatments and approaches for tackling cancer development will be discussed. Students will also learn about the experimental approaches to understanding cancer.