Define what a gene allele is and what we mean by DOMINANT AND RECESSIVE alleles

Explain why an allele of a gene encoding a working version of an enzyme is usually dominant over a mutant allele that encodes a non-working enzyme

Define HAPLOINSUFFICIENCY and the nature of DOMINANT NEGATIVE alleles, give examples to illustrate how these work

Give one example where alleles of SEVERAL genes combine to give different phenotypes

Define epistasis and explain it using an example

Give some specific examples of modifier genes and discuss their general importance in genetics

Describe the genetic effects of penetrance and expressivity using Huntington’s disease as an example

Explain what a genetic map is, the nature of genetic linkage and recombination, and how by measuring recombination we can produce genetic maps